Predicting levodopa-induced dyskinesia
نویسندگان
چکیده
منابع مشابه
Levodopa-induced dyskinesia and thalamotomy.
Levodopa-induced dyskinesia of the limbs in thirteen cases of Parkinsonism, which was choreic, ballistic or dystonic in type, was alleviated almost completely by stereotaxic surgery using a microelectrode technique for the ventralis oralis anterior and posterior nuclei of the thalamus, but much less by the ventralis intermedius nucleus. Control of levodopa-induced dyskinesias by thalamic lesion...
متن کاملLevodopa-induced dyskinesia and striatal signaling pathways.
P arkinson’s disease (PD) is the most common movement disorder, affecting 2% of individuals over age 60 (1). The cardinal clinical features of PD are resting tremor, rigidity, bradykinesia, and postural instability, which are often accompanied by autonomic, cognitive, and emotional disturbances. The neuropathological hallmark of PD is the degeneration of dopaminergic neurons in the substantia n...
متن کاملLevodopa-Induced Dyskinesia: Medical and Surgical Management
Although levodopa therapy remains the most effective symptomatic treatment for PD, its usefulness may be limited by these motor complications, which result in deterioration in quality of life. Levodopa-induced dyskinesia (LID) is characterized by a variety of hyperkinetic movements. Although chorea and dystonia are the most common manifestations of LID, stereotypies, tics, myoclonus, or ballism...
متن کاملDiabetes Increases the Incidence of Levodopa-Induced Dyskinesia in Parkinson’s Disease; A Case-Control Study
Background and Objective: Dyskinesia is a debilitating complication of Parkinsonchr('39')s disease (PD), which appears due to some known risk factors. The effect of diabetes and high plasma glucose on the manifestation of dyskinesia has been evaluated in just a few previous reports. The current study aimed to assess the mentioned correlation. Materials and Methods: In this case-control study, ...
متن کاملLevodopa-induced dyskinesia is strongly associated with resonant cortical oscillations.
The standard pharmacological treatment for Parkinson's disease using the dopamine precursor levodopa is unfortunately limited by gradual development of disabling involuntary movements for which the underlying causes are poorly understood. Here we show that levodopa-induced dyskinesia in hemiparkinsonian rats is strongly associated with pronounced 80 Hz local field potential oscillations in the ...
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ژورنال
عنوان ژورنال: Arquivos de Neuro-Psiquiatria
سال: 2020
ISSN: 1678-4227,0004-282X
DOI: 10.1590/0004-282x20200023